These work miracles, as someone with a lot of ongoing skin issues. As long as the skin around the injury is dry, these stay adhered very well, even when you wash your hands. In fact, hands are a very important use case for me, since it keeps the injury site clean and doesn't collect water from handwashing the way cloth bandaids do. That said- depending on if you need some very creative angles on your hands, the All Health brand might be better, because it's much more flexible- though All Health doesn't cushion against pressure as well because of that. Band-aid brand is especially good for mostly-flat stretches of skin, or ones that curve only a little. (Band-aid brand is also eligible to be paid for with FSA or HSA funds, while I have not been able to do so for All Health.) For both brands (and indeed the others I've used as well), though, if a little water gets under the edges, it will start to peel up early and you'll want to replace the bandage with a new one- water getting underneath will have the same effect on the bandage as the fluid draining from the wound, which is to say it will absorb it and stop sticking. Relatedly, if a wound is seeping too rapidly (or bleeding more than a very little bit), these won't have time to absorb the fluid and it will just build up under the bandage until it leaks out (though at least it still won't stick to the wound site in that case). In that case, I would recommend starting off with a more traditional bandage with some kind of medicated ointment (neosporin or some other kind of antibacterial, or, if you've cleaned it thoroughly and it doesn't look like any chance of infection, zinc oxide ointment to help dry out the wound a little), and wait until the wound has healed a little more and seeps a little less. Then you can switch to these hydroseal bandaids, which seal out contaminants and cushion the wound. (Be aware that these bandaids don't work particularly well with any ointments under them on the wound. The residue of zinc oxide when it's dry seems to be fine, and any ointment that dries completely might be fine, but it's even recommended on the bandaid box to skip any ointments, creams, or lotions, to ensure they will stick correctly.) In my experience, if the wound is still seeping even a little blood, these will be less effective in healing. They work best on wounds with small amounts of clear discharge only. Even if the bandaid itswlf seems to behave the same in both cases. I don't know why. For blisters, either you can just stick one on top of the closed blister to cushion it and absorb any disrcharge through the skin; or you can carefully pierce the blister, clean it thouroughly with isopropyl alcohol, and then put the hydroseal bandaid on it; or you can carefully remove the entire flap of skin over the blister, clean it with isopropyl, and then put one of these on it. In my experience, all these have their place- I would leave the blister unpopped for as long as possible so the skin underneath can start to regenerate in natural conditions, but if it's starting to become painful due to the pressure of fluid buildup or physical pressure on the blister location pushing the fluid around and causing the skin within the blister to tear, you may find piercing it helps. In any case, making sure the whole thing is very clean is important. And for blisters in particular (as opposed to scrapes with fluid discharge), no matter whether you're leaving them closed or not, keep the hydroseal bandaid on as long as possible, and don't try and remove it before it starts coming off on its own. This is important in general, but for blisters it seems to be even more important. Not sure why. Also, IMPORTANT: Don't use these over a wound that shows any sign of infection (and/or little tiny blisters the side fo a pinhead appearing around the initial wound site). That will just spread any bacteria around, and then the infection will get worse and then your skin doctor will frown at you and you'll end up needing a bunch of oral antibiotics. Which, in my experience, is troublesome. Learn from my experiences, and if you see anything even vaguely like an infection, look into the appropriate medicated ointments and traditional non stick bandages instead. Maybe consult a doctor about it if you can. If you need those waterproof, I'm pretty sure clear bandage covering adhesive sheets exist, although I have not yet tried them. Overall these are a very important part of my medical supplies and work absolute wonders- as long as they are used for the correct situations. Also, prices fluctuate a lot, so check Amazon often, and look up different bulk listings, and compare the unit prices. Amazon has still be usually better than the local stores, but it's not guaranteed.